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For what it's worth, I'll slightly expand what I said in the other thread.
You should vote to close if you think the question needs to be taken out of circulation (i.e. people should not post answers) for some reason. Typically the reason will be one of the following.
You should vote a question down if you think it's a bad question. Sometimes you'll both vote to close and vote down, but it can happen that a question doesn't need to be closed yet is still a bad question. I think I've downvoted a couple of [big-list] questions because I thought it was stupid to compile a big list of whatever it was, even though the question was fairly to-the-point and on-topic ... it's hard to bring an example to mind. On the other hand, it's pretty common that I think a question should be closed, but I don't want to vote it down. Perhaps it doesn't belong on MO, but is a perfectly interesting question, or perhaps it's ambiguous, but is probably interesting. I don't think I've ever voted to close and voted up a question.
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